Beyond Botox: Comparing FDA-Approved Neuromodulators for Smoother Skin

When it comes to aesthetic treatments, Botox is one of the most well-known names in the industry. But it’s far from the only option. Several FDA-approved injectables offer similar wrinkle-reducing benefits, including Daxxify, Dysport, Jeuveau, and Xeomin. While they all fall under the category of neuromodulators, each product has subtle differences worth exploring.

What Are Neuromodulators?

Neuromodulators temporarily relax targeted facial muscles by blocking nerve signals. This smooths out dynamic wrinkles—like frown lines, forehead lines, and crow’s feet—caused by repetitive muscle movement. All of these products contain botulinum toxin type A, but differ in formulation, onset time, spread, and duration.


Botox

Botox was FDA-approved in 2002 to treat frown lines between the brows and later expanded to include forehead lines and crow’s feet.

  • Results appear: in 3–5 days (full effect in up to 2 weeks)
  • Duration: about 3–4 months
  • Best for: patients seeking a trusted, time-tested option

Dysport

Like Botox, Dysport works by blocking nerve signals to relax muscles, but may take effect faster, sometimes within just 24 hours.

  • Results appear: within 1–2 days
  • Duration: may be slightly shorter than Botox
  • Best for: first-time patients or those wanting quicker results

Daxxify

Approved in late 2022, Daxxify is a newer neuromodulator with a unique formulation designed to last longer than other options.

  • Results appear: similar to Botox
  • Duration: longer-lasting in some patients
  • Best for: patients looking for extended wrinkle-smoothing effects

Jeuveau

Nicknamed “Newtox,” Jeuveau was approved in 2019 and also uses botulinum toxin type A.

  • Results appear: in 3–5 days
  • Duration: 3–6 months
  • Best for: patients seeking a modern alternative with comparable results to Botox

Xeomin

Xeomin is unique for its “naked” formula—meaning it’s free of accessory proteins, which may reduce the risk of developing resistance over time.

  • Results appear: around 4 days
  • Duration: 3–6 months
  • Best for: patients wanting a cleaner formulation

Which Option Is Right for You?

Each neuromodulator has its own strengths, from fast onset to extended longevity or simplified ingredients. The right choice depends on your goals, skin type, treatment area, and how your body responds. A qualified aesthetic provider can help guide you through the best option for your needs.

Ready to explore your options? Book a consultation and let our experts help you enhance your natural beauty—safely and professionally.

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